Genomics and Proteomics

Genome = all of the DNA sequences (all of the genes) in an organism

Proteome = all of the protein sequences encoded in the genome

Goal - understand how living things function

- study the structure and function of the entire genome and proteome

* thousands of genes (genomics)

* thousands of proteins (proteomics)

Strategy - determine the DNA sequences of entire genomes

- map the locations of all genes on the chromosomes

* marker-assisted breeding

- elucidate the regulation of gene expression

- elucidate the structure and function of all proteins

Methods - automated DNA sequencing of entire genomes

- computer analysis of DNA sequence data (bioinformatics)

- gene chips test expression of thousands of genes at once

- mass spectrometry determines the sequence of the protein

- modeling methods for computer analysis of protein 3D structure

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